Effect of a specific cysteinyl leukotriene antagonist, pranlukast, on antigen-induced cysteinyl leukotriene-mediated rhinitis in guinea pigs
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- Fujita Manabu
- Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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- Yonetomi Yasuo
- Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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- Takeda Hiroshi
- Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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- Nakagawa Naoki
- Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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- Kawabata Kazuhito
- Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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- Ohno Hiroyuki
- Minase Research Institute, Ono Pharmaceutical Co., Ltd.
書誌事項
- タイトル別名
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- Effects of a Specific Cysteinyl Leukotriene Antagonist, Pranlukast, on Antigen-Induced Cysteinyl Leukotriene-Mediated Rhinitis in Guinea Pigs.
- Effects of a Specific Cysteinyl Leukotr
この論文をさがす
抄録
To examine the effects of a specific cysteinyl leukotriene (cysLT) antagonist, pranlukast, on allergic rhinitis, antigen-induced rhinitis in guinea pigs was modified by pretreatment with an cyclooxygenase inhibitor (indomethacin) followed by an H1-blocker (pyrilamine). Intranasal ovalbumin (OVA) administration in actively sensitized guinea pigs resulted in concentration-dependent increases in nasal permeability and nasal airway resistance (NAR). Although pyrilamine (1 mg/kg, i.v.) abolished these antigen-induced changes, pretreatment with indomethacin (5 mg/kg, i.v.) followed by pyrilamine enhanced these responses to a degree similar to that observed with OVA challenge alone. Analyses of nasal perfusate in indomethacin/pyrilamine-pretreated animals showed that cysLTs increased by 270.8%, whereas thromboxane B2 decreased by 88.3% as compared with those on challenged with OVA alone. Oral administration of pranlukast (1-10 mg/kg) dose-dependently prevented increases in nasal permeability and NAR of indomethacin/pyrilamine-pretreated animals. However, an anti-allergic agent, azelastine, did not affect these responses. These results indicate that pranlukast suppresses antigen-induced cysLT-mediated responses of allergic rhinitis in actively sensitized guinea pigs. A cysLT antagonist, pranlukast, may thus prevent cysLT-mediated symptoms of allergic rhinitis.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 75 (4), 347-353, 1997
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679261231744
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- NII論文ID
- 10008190403
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1cXhtVOl
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- ISSN
- 13473506
- 00215198
- http://id.crossref.org/issn/00215198
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- NDL書誌ID
- 4371100
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- PubMed
- 9469640
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可