New Curcuminoids Isolated from Zingiber cassumunar Protect Cells Suffering from Oxidative Stress: A Flow-Cytometric Study Using Rat Thymocytes and H2O2.

• Nagano Takayuki

  Laboratories of Cellular Signaling and Bioorganic Chemistry, Faculty of Integrated Arts and Sciences, The University of Tokushima Graduate School of Pharmaceutical Sciences, Osaka University

• Oyama Yasuo

  Laboratories of Cellular Signaling and Bioorganic Chemistry, Faculty of Integrated Arts and Sciences, The University of Tokushima

• Kajita Noriko

  Laboratories of Cellular Signaling and Bioorganic Chemistry, Faculty of Integrated Arts and Sciences, The University of Tokushima

• Chikahisa Lumi

  Laboratories of Cellular Signaling and Bioorganic Chemistry, Faculty of Integrated Arts and Sciences, The University of Tokushima Cancer Research Laboratory, Taiho Pharmaceutical Co., Ltd.

• Nakata Mami

  Laboratories of Cellular Signaling and Bioorganic Chemistry, Faculty of Integrated Arts and Sciences, The University of Tokushima

• Okazaki Eisuke

  Laboratories of Cellular Signaling and Bioorganic Chemistry, Faculty of Integrated Arts and Sciences, The University of Tokushima

• Masuda Toshiya

  Laboratories of Cellular Signaling and Bioorganic Chemistry, Faculty of Integrated Arts and Sciences, The University of Tokushima

書誌事項

タイトル別名

• New Curcuminoids Isolated from Zingiber

抄録

Effects of new complex curcuminoids (cassumunin A and cassumunin B) isolated from tropical ginger, Zingiber cassumunar, were examined in dissociated rat thymocytes suffering from oxidative stress induced by 3 mM hydrogen peroxide by using a flow cytometer and ethidium bromide. The effects were compared with those of curcumin, a natural antioxidant, whose chemical structure is included in those of cassumunins A and B. Pretreatment of rat thymocytes with the respective cassumunins at concentrations ranging from 100 nM to 3 μM dose-dependently prevented the hydrogen peroxide (H₂0₂)-induced decrease in cell viability. It had the same action, although less effective, against the treatment with cassumunin A or B (3 μM) immediately after or 60 min after start of the oxidative stress. Respective potencies of cassumunins A and B in protecting the cells suffering from H₂0₂-induced oxidative stress were greater than that of curcumin. It is suggested that cassumunins A and B may possess a potent protective action on living cells suffering from oxidative stress.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 75 (4), 363-370, 1997

  公益社団法人 日本薬理学会

キーワード

• Curcumin
• Curcuminoid
• Zingiber cassumunar
• Flow cytometry
• Oxidative stress

詳細情報

• CRID: 1390001204284518272
• NII論文ID: 10008190449
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.75.363
• COI: 1:CAS:528:DyaK1cXhtVOr
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 4371102
• PubMed: 9469642
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4371102
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819312879?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819312879?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/1998086641
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可