Effect of Human Neutrophil Elastase on Tracheal Mucociliary Transport in Anesthetized Quails

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著者

    • ISOHAMA Yoichiro
    • Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
    • TAKAHAMA Kazuo
    • Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University
    • MIYATA Takeshi
    • Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University

抄録

We investigated the effect of human neutrophil elastase (HNE) on tracheal mucociliary transport in anesthetized quails. Topical application of HNE (30-300 μg/kg) to tracheal mucosa dosedependently decreased mucociliary transport velocity (MCTV). The HNE (300 μg/kg)-induced decrease in MCTV was blocked by ONO-5046·Na (sodium <I>N</I>-[2-[4-(2, 2-dimethylpropionyloxy)phenyl-sulfonylamino]benzoyl]aminoacetate tetrahydrate) (3-30 mg/kg, i.m.), a specific neutrophil elastase inhibitor. Furthermore, we found that HNE increased DNA, fucose and protein contents of tracheal lavages, and the increases were also reverted by ONO-5046·Na. These results indicated that HNE decreased tracheal mucociliary transport, and the decrease may be, at least in part, ascribed to the deterioration of tracheal secretions.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 75(4), 439-442, 1997-12-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008190720
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4371111
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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