Enhancement of Membrane Damage by Saponins Isolated from Acacia auriculiformis

この論文にアクセスする

この論文をさがす

著者

抄録

Acaciaside A and B, two acylated triterpenoid bisglycosides isolated from the funicles of <I>Acacia auriculiformis</I>, are known to have antihelmintic activity. Since the saponins contain a conjugated unsaturated system that is highly susceptible to peroxidation, we investigated the interaction of saponins and membrane using rat liver microsomes as our model. Microsomal membranes were incubated with saponins at 30°C for 2 hr. Following incubation, lipid peroxidation was measured in terms of malondialdehyde and conjugated diene. Our results showed that incubation of microsomal membranes with saponins increased both malondialdehyde and conjugated diene. The results suggest that in our model, saponins enhance the membrane lipid peroxidation.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 75(4), 451-454, 1997-12-01

    The Japanese Pharmacological Society

参考文献:  11件中 1-11件 を表示

各種コード

  • NII論文ID(NAID)
    10008190768
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4371114
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ