Enhancement of Membrane Damage by Saponins Isolated from Acacia auriculiformis.
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- Babu Santi Prasad Sinha
- Parasitology Laboratory, Department of Zoology, Visva-Bharati University
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- Sarkar Debapriya
- Environmental Toxicology Laboratory, Department of Zoology, Visva-Bharati University
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- Ghosh Naba Kumar
- Parasitology Laboratory, Department of Zoology, Visva-Bharati University
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- Saha Arpita
- Parasitology Laboratory, Department of Zoology, Visva-Bharati University
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- Sukul Nirmal Chandra
- Parasitology Laboratory, Department of Zoology, Visva-Bharati University
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- Bhattacharya Shelley
- Environmental Toxicology Laboratory, Department of Zoology, Visva-Bharati University
Bibliographic Information
- Other Title
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- Enhancement of Membrane Damage by Sapon
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Abstract
Acaciaside A and B, two acylated triterpenoid bisglycosides isolated from the funicles of Acacia auriculiformis, are known to have antihelmintic activity. Since the saponins contain a conjugated unsaturated system that is highly susceptible to peroxidation, we investigated the interaction of saponins and membrane using rat liver microsomes as our model. Microsomal membranes were incubated with saponins at 30°C for 2 hr. Following incubation, lipid peroxidation was measured in terms of malondialdehyde and conjugated diene. Our results showed that incubation of microsomal membranes with saponins increased both malondialdehyde and conjugated diene. The results suggest that in our model, saponins enhance the membrane lipid peroxidation.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 75 (4), 451-454, 1997
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679261419776
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- NII Article ID
- 10008190768
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- NII Book ID
- AA00691188
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- COI
- 1:STN:280:DyaK1c7ivFGmtA%3D%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4371114
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- PubMed
- 9469654
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed