The AMPA-Receptor Antagonist YM90K Reduces AMPA Receptor-Mediated Excitotoxicity in Rat Hippocampal Cultures

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著者

    • Ohno Kazushige OHNO Kazushige
    • Neuroscience Research, Pharmacology Laboratiries, Institute for Drug Discavery Research, Yamanouchi Pharmaceutical Co., Ltd.
    • SAKAMOTO Shuichi
    • Neuroscience Research, Pharmacology Laboratiries, Institute for Drug Discavery Research, Yamanouchi Pharmaceutical Co., Ltd.
    • YAMAGUCHI Tokio
    • Neuroscience Research, Pharmacology Laboratiries, Institute for Drug Discavery Research, Yamanouchi Pharmaceutical Co., Ltd.

抄録

The effects of YM90K on α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor-mediated excitotoxicity were investigated using kainate, AMPA and cyclothiazide in rat hippocampal cultures. YM90K had neuroprotective actions against both kainate toxicity and cyclothiazideenhanced AMPA toxicity. YM90K induced a parallel and rightward shift of both kainate and AMPA dose-response curves. The application of YM90K even 3 hr after the start of kainate exposure significantly reduced kainate toxicity. These results indicate that YM90K protects neurons against AMPA receptor-mediated toxicity at an agonist site on the AMPA receptor and that YM90K protects against AMPA receptor-mediated toxicity even if applied after neurotoxic insult.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 76(1), 105-108, 1998-01

    The Japanese Pharmacological Society

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キーワード

各種コード

  • NII論文ID(NAID)
    10008191259
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4395864
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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