Effect of Muscarinic Agonist on Overflow Incontinence Induced by Bilateral Pelvic Nerve Transection in Rats

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The effect of bethanechol, a muscarinic agonist, was studied by cystometrography in conscious rats with bilateral pelvic nerve (PN) lesions. In sham-operated rats, the transvesical infusion of saline elicited regularly micturition. The micturition was abolished by the bilateral PN transection, resulting in overflow incontinence. Bethanechol (30 mg/kg), administered orally to denervated rats, significantly increased the micturition frequency. Therefore, the micturition seems to be largely dependent upon muscarinic receptors of the bladder, and the finding supports the clinical effect of bethanechol. Moreover, this animal model may be useful for studying the overflow incontinence from detrusor failure of neuropathic origin.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 76(1), 109-111, 1998-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008191274
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4395865
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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