Effect of Tacrolimus Hydrate (FK506) Ointment on Spontaneous Dermatitis in NC/Nga Mice

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著者

    • KISHI Shinichi
    • Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
    • SATO Sachio
    • Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
    • OGAWA Toshikazu
    • Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
    • TSUDZUKI Masaoki
    • Laboratory of Animal Breeding and Genetics, Faculty of Applied Biological Science, Hiroshima University
    • MATSUDA Hiroshi
    • Department of Veterinary Clinic, Faculty of Agriculture, Tokyo University of Agriculture and Technology
    • WADA Adumi
    • Department of Laboratory Animal Science, College of Agriculture, University of Osaka Prefecture
    • ESAKI Kozaburo
    • Department of Laboratory Animal Science, College of Agriculture, University of Osaka Prefecture

抄録

The effect of tacrolimus hydrate (FK506) ointment on spontaneous dermatitis in NC/Nga (NC) mice was examined. FK506 ointment (0.1 – 1%) suppressed the development of dermatitis and was also therapeutically effective against established dermatitis. Increases in CD4-positive T cells (helper T cells), mast cells, eosinophils and immunostaining of interleukin (IL)-4, IL-5 and IgE were confirmed in the skin of the NC mice, and FK506 ointment suppressed all of these changes. Increased plasma IgE was also confirmed in the NC mice, and treatment with FK506 ointment reduced the plasma IgE level. These results suggested that FK506 suppressed the dermatitis by inhibiting the activation of inflammatory cells and by blocking the cytokine network in the skin of the NC mice. The commercially available steroid ointments showed only marginal effect on the development of dermatitis and showed some signs of side effects such as alopecia or atrophy of the skin. The effect of the steroids might have been masked by these side effects because the steroids showed similar inhibitory effects on the skin histopathological changes and the increase of plasma IgE. From these results, FK506 ointment can be expected to be a useful drug for atopic dermatitis.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 76(2), 175-183, 1998-02

    The Japanese Pharmacological Society

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被引用文献:  16件中 1-16件 を表示

各種コード

  • NII論文ID(NAID)
    10008191512
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4416243
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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