Possible Involvement of K_<ATP> Channel Activation in Depressor Responses to Vasoactive Neuropeptides in Rats

この論文にアクセスする

この論文をさがす

著者

抄録

I.v. bolus injections of vasoactive intestinal polypeptide (VIP) (0.3 or 1 μg/kg), calcitonin gene-related peptide (CGRP) (0.3 μg/kg) or substance P (0.1 μg/kg) to anesthetized rats reduced blood pressure, accompanied by slight increases in heart rate. Cromakalim (0.3 μg/kg/min) infused i.v. significantly potentiated the depressor responses to VIP and CGRP, but not those to substance P and acetylcholine (ACh) (0.1 μg/kg). Glibenclamide (20 mg/kg, i.v.) significantly inhibited not only the depressor responses to VIP and CGRP, but also the augmentation of the effects of the two agents by cromakalim. These results suggest that the depressor responses to VIP and CGRP are mediated in part through K<SUB>ATP</SUB> channel activation.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 76(2), 227-231, 1998-02

    The Japanese Pharmacological Society

参考文献:  15件中 1-15件 を表示

各種コード

  • NII論文ID(NAID)
    10008191712
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4416251
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ