Inhibition by γ-Aminobutyric Acid System Activation of Epileptic Seizures in Spontaneously Epileptic Rats

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  • Fukao Kenjiro
    Department of Pharmacology, Faculty of Medicine, Kyoto University
  • Momiyama Toshihiko
    Department of Pharmacology, Faculty of Medicine, Kyoto University Present address: 2nd Department of Physiology, Nagasaki University School of Medicine
  • Ishihara Kumatoshi
    Department of Pharmacology, Hiroshima University School of Medicine
  • Ujihara Hisamitsu
    Department of Neuropsychiatry, Kochi Medical School
  • Fujita Yasuhiko
    Institute of Laboratory Animals, Faculty of Medicine, Kyoto University
  • Taniyama Kohtaro
    Department of Pharmacology, Nagasaki University School of Medicine
  • Serikawa Tadao
    Institute of Laboratory Animals, Faculty of Medicine, Kyoto University
  • Sasa Masashi
    Department of Pharmacology, Hiroshima University School of Medicine

書誌事項

タイトル別名
  • Inhibition by .GAMMA.-Aminobutyric Acid System Activation of Epileptic Seizures in Spontaneously Epileptic Rats.
  • Inhibition by ガンマ Aminobutyric Acid Sys

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抄録

The effects of muscimol, a γ-aminobutyric acid (GABA)A-receptor agonist, and aminooxy-acetic acid (AOAA), an inhibitor of GABA-converting enzyme, on tonic and absence-like seizures in spontaneously epileptic rats (SER: zi/zi, tm/tm) were investigated to elucidate whether GABAergic function operates normally in these animals. Muscimol at doses of 1 and 3 mg/kg (i.p.) induced high-voltage slow waves in the cortical and hippocampal EEG of SER, although the behavioral observation suggested inhibition of absence-like seizures. Similar high-voltage slow waves were also observed in the cortical and hippocampal EEG of normal rats with muscimol (1 and 3 mg/kg). Tonic convulsions in SER were dose-dependently inhibited by muscimol. AOAA (3 and 10 mg/kg, i.v.) inhibited both tonic and absence-like seizures in SER, although there were no obvious changes in EEG pattern. The inhibitory effects of AOAA on tonic convulsions appeared more slowly and lasted longer than those on absence-like seizures. Cerebral, hippocampal and cerebellar GABA levels were significantly higher in SER than the normal Kyo:Wistar and zitter rat (zi/zi), which were both the parent strains. These findings suggest that GABA receptors and GABAergic neurons are functional in SER and that the GABA system is involved in the inhibition of both seizures.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 76 (4), 387-396, 1998

    公益社団法人 日本薬理学会

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