Role of Bradykinin in the Reduction of Left Ventricular Hypertrophy Induced by Angiotensin-Converting Enzyme Inhibitors in Spontaneously Hypertensive Rats

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抄録

We examined the effects of icatibant, a specific bradykinin B<SUB>2</SUB>-receptor antagonist, on the regression of left ventricular mass (LVM) induced by angiotensin converting enzyme (ACE) inhibitors, ramipril and imidapril, in spontaneously hypertensive rats. Both ramipril and imidapril lowered blood pressure equally, which were not influenced by icatibant. Icatibant did not alter the regressive effect of imidapril, while it showed a tendency to increase LVM in the ramipril-treated rats. The changes of LVM induced by icatibant were significantly different between the ramipril- and the imidapril-treated rats, suggesting that the role of bradykinin in the antihypertrophic effect might differ among ACE inhibitors.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 76(4), 431-434, 1998-04-01

    The Japanese Pharmacological Society

参考文献:  10件中 1-10件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10008192760
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4462600
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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