Inhibitory Effects of Corymine-Related Compounds on Glycine Receptors Expressed in Xenopus Oocytes

この論文にアクセスする

この論文をさがす

著者

    • SUBHADHIRASAKUL Sanan
    • Department of Pharmaceutical Botany and Pharmacognosy, Faculty of Pharmaceutical Sciences, Prince of Songkhla University
    • AIMI Norio
    • Faculty of Pharmaceutical Sciences, Chiba University
    • WATANABE Hiroshi
    • Department of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University

抄録

We examined the effects of 4 corymine-related compounds on glycine-induced chloride current in <I>Xenopus</I> oocytes. Dihydrocorymine, <I>N</I>-demethyl-3-epi-dihydrocorymine and deformylcorymine dose-dependently decreased the glycine current with IC<SUB>50</SUB> values of 34, 37 and 55 μM, respectively. The effect of these compounds on the glycine current was more potent than that of pleiocarpamine (IC<SUB>50</SUB> > 1 mM). <I>N</I>-Demethyl-3-epi-dihydrocorymine and dihydrocorymine, at 100 μM, also decreased the γ-aminobutyric acid-induced current by 65% and 22%, respectively, whereas deformylcorymine and pleiocarpamine failed. The inhibitory action of deformylcorymine on the glycine current was noncompetitive. These results suggest that deformylcorymine is a novel specific noncompetitive glycine receptor antagonist. The structure-activity relationship of these compounds was discussed.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 77(2), 169-172, 1998-06-01

    The Japanese Pharmacological Society

参考文献:  8件中 1-8件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008193068
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4514093
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
ページトップへ