Histamine H_3 Receptor-Mediated Inhibition of Excitatory Synaptic Transmission in the Rat Dentate Gyrus In Vivo

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We investigated the effects of histamine H<SUB>3</SUB>-receptor ligands on hippocampal synaptic transmission by using anesthetized rats in vivo. The medial perforant path was stimulated, and the population excitatory postsynaptic potential (pEPSP) and population spike were recorded from the granule cell layer of the dentate gyrus. Intracerebroventricular injection of the H<SUB>3</SUB>-receptor agonist (<I>R</I>)-α-methylhistamine decreased both the pEPSP and population spike, while H<SUB>3</SUB>-receptor antagonists, clobenpropit and thioperamide, increased both the pEPSP and population spike. These results suggest that the histaminergic system plays a role in inhibition of hippocampal synaptic excitation via the H<SUB>3</SUB> receptor.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 77(3), 251-255, 1998-07-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008193306
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4525742
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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