Pharmacological Studies on the Novel Antiallergic Drug HQL-79: 1. Antiallergic and Antiasthmatic Effects in Various Experimental Models
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- Matsushita Nobutoshi
- Present address for correspondence: Pharmacological Research Group, Bioclinical Research Division, Rohto Pharmaceutical Co., Ltd.
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- Hizue Masanori
- New Drug Research Department, High Quality-Life Research Laboratories, Bio-Medical Division, Sumitomo Metal Industries, Ltd.
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- Aritake Kosuke
- New Drug Research Department, High Quality-Life Research Laboratories, Bio-Medical Division, Sumitomo Metal Industries, Ltd.
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- Hayashi Kumi
- New Drug Research Department, High Quality-Life Research Laboratories, Bio-Medical Division, Sumitomo Metal Industries, Ltd.
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- Takada Ayumi
- New Drug Research Department, High Quality-Life Research Laboratories, Bio-Medical Division, Sumitomo Metal Industries, Ltd.
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- Mitsui Kazuhiko
- New Drug Research Department, High Quality-Life Research Laboratories, Bio-Medical Division, Sumitomo Metal Industries, Ltd.
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- Hayashi Masatoshi
- New Drug Research Department, High Quality-Life Research Laboratories, Bio-Medical Division, Sumitomo Metal Industries, Ltd.
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- Hirotsu Ichiro
- New Drug Research Department, High Quality-Life Research Laboratories, Bio-Medical Division, Sumitomo Metal Industries, Ltd.
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- Kimura Yoshiyuki
- New Drug Research Department, High Quality-Life Research Laboratories, Bio-Medical Division, Sumitomo Metal Industries, Ltd.
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- Tani Tadato
- New Drug Research Department, High Quality-Life Research Laboratories, Bio-Medical Division, Sumitomo Metal Industries, Ltd.
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- Nakajima Hiromichi
- New Drug Research Department, High Quality-Life Research Laboratories, Bio-Medical Division, Sumitomo Metal Industries, Ltd.
書誌事項
- タイトル別名
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- Pharmacological Studies on the Novel Antiallergic Drug HQL-79:I. Antiallergic and Antiasthmatic Effects in Various Experimental Models.
- Pharmacological Studies on the Novel An
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The effects of oral administration of 4-benzhydryloxy-1-{3-(1H-tetrazol-5-yl)-propyl}piperidine (HQL-79), a newly synthesized antiallergic drug, in various experimental allergic and asthmatic models were investigated. HQL-79 markedly inhibited immediate hypersensitivity reactions such as passive cutaneous anaphylaxis in rats, antigen-induced bronchoconstriction and nasal vascular permeability in actively sensitized guinea pigs, like epinastine and ketotifen did. Airway eosinophilia in repeatedly antigen-exposed guinea pigs was suppressed by chronic administration of HQL-79 for 2 weeks. In another experiment, the antigen-induced late asthmatic response (LAR) in metyrapone-treated guinea pigs was also ameliorated by chronic treatment with HQL-79. Moreover, HQL-79 partially inhibited the toluene diisocyanate-induced delayed-type hypersensitivity (DTH) reaction in mice when administered chronically during the immunization period. The corticosteroid dexamethasone inhibited the airway inflammatory responses in guinea pigs and the DTH in mice. These results indicate that HQL-79 has potent inhibitory effects on the immediate hypersensitivity reactions, and when administered chronically, it also inhibits airway eosinophilia, LAR and DTH, similarly to corticosteroids.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 78 (1), 1-10, 1998
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204286812416
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- NII論文ID
- 10008193537
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- NII書誌ID
- AA00691188
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- DOI
- 10.1254/jjp.78.1
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- COI
- 1:CAS:528:DyaK1cXmtlCktbw%3D
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- ISSN
- 13473506
- 00215198
- http://id.crossref.org/issn/00215198
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- NDL書誌ID
- 4565697
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- PubMed
- 9804056
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4565697
- https://api.elsevier.com/content/article/PII:S0021519819310625?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819310625?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/78/1/78_1_1/_pdf
- https://search.jamas.or.jp/link/ui/1999001060
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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