Protective Effect of the Mold Monascus Anka Against Acetaminophen-Induced Liver Toxicity in Rats

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Antioxidant and hepatoprotective actions of the mold <I>Monascus anka</I> (also called <I>Beni-Koji</I> in Japan) against acetaminophen (AAP)-induced liver toxicity were investigated. Serum aspartate aminotransferase and glutathione <I>S</I>-transferase (GST) activities increased by AAP (180 mg/kg, i.p.) treatment were depressed when the <I>Beni-Koji</I> preparation (4 ml/kg, i.p.) was given 15 and 1 hr before AAP administration. The decrease in liver cytosolic GST activity by AAP, reflecting the release of the enzyme into serum, was also blocked by the mold. Cytochrome P450 activity was inhibited by the <I>Beni-Koji</I> preparation. These results suggest that <I>M. anka</I> prevents AAP-induced liver toxicity by both antioxidant action and the inhibition of AAP metabolism.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 78(1), 79-82, 1998-09

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008193814
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4565707
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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