Involvement of μ-Receptor in Endogenous Opioid Peptide-Mediated Inhibition of Acetylcholine Release From the Rat Stomach

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We examined the effect of endogenous opioid peptides on vagally evoked release of acetylcholine (ACh) from the isolated, vascularly perfused rat stomach. The vagus nerves were electrically stimulated twice at 2.5 Hz for 2 min, and test substances were administered during the second stimulation. β-Endorphin (10<SUP>-7</SUP> and 3×10<SUP>-7</SUP> M), an endogenous nonselective agonist of μ-receptors, inhibited the release of ACh. However, [Leu<SUP>5</SUP>]-enkephalin, an endogenous nonselective agonist of δ-receptors, and U-50488, a κ-receptor agonist, had no effect at a higher dose of 10<SUP>-6</SUP> M. β-Endorphin-induced inhibition was abolished by naloxone. Endomorphins 1 and 2 (3×10<SUP>-7</SUP> and 10<SUP>-6</SUP> M), endogenous selective agonists of μ-receptors, also inhibited the release of ACh. These results suggest that the μ-receptor is involved in the endogenous opioid peptide-induced inhibition of the release of ACh from the rat stomach.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 78(1), 93-95, 1998-09

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008193858
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4565710
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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