Effects of Concanavalin A Treatment on CD8 mRNA Expression in Mouse Liver.
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- Okamoto Toshihiro
- Research Laboratories, Nippon Chemiphar Co., Ltd.
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- Nakano Yoshihisa
- Research Laboratories, Nippon Chemiphar Co., Ltd.
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- Tsuzuike Naoki
- Research Laboratories, Nippon Chemiphar Co., Ltd.
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- Hara Kaoru
- Research Laboratories, Nippon Chemiphar Co., Ltd.
Bibliographic Information
- Other Title
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- Effects of Concanavalin A Treatment on
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Abstract
The administration of concanavalin A (Con A) (0.2 mg/mouse) into mice induced significant elevation of plasma alanine aminotransferase (ALT) at 8.5 hr after Con A treatment. CD8 mRNA, which is a marker of cytotoxic T-cell, was strongly induced at 16 and 24 hr after Con A treatment. Although pretreatment with cyclosporine A (CsA) (50 and 100 mg/kg, i.p.) inhibited Con A-induced elevation of plasma ALT, it did not inhibit Con A-induced CD8 mRNA expression. Morphological study revealed lymphoid cell infiltration in the liver, but the lymphoid cells were not present at the site of hepatocyte necrosis. These results suggest that Con A-induced CD8+ T-cell infiltration has a minimal effect in the development of hepatitis.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 78 (1), 97-99, 1998
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204286883072
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- NII Article ID
- 10008193873
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1cXmtlCkurg%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4565711
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- PubMed
- 9804070
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4565711
- https://api.elsevier.com/content/article/PII:S0021519819310765?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819310765?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/78/1/78_1_97/_pdf
- https://search.jamas.or.jp/link/ui/1999000461
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed