Effect of the 5-Hydroxytryptamine3(5-HT3)-Receptor Antagonist KB-R6933 0n Experimental Diarrhea Models
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- Ozaki Akio
- Pharmaceuticals R&D Center, Kanebo, Ltd.
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- Yoshidomi Mikio
- Pharmaceuticals R&D Center, Kanebo, Ltd.
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- Sukamoto Takayuki
- Pharmaceuticals R&D Center, Kanebo, Ltd.
書誌事項
- タイトル別名
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- Effect of the 5-Hydroxytryptamine3 (5-HT3)-Receptor Antagonist KB-R6933 on Exerimental Diarrhea Models.
- Effect of the 5 Hydroxytryptamine3 5 HT3 Receptor Antagonist KB-R6933 0n Experimental
- Effect of the 5-Hydroxytryptamine3 (5-HT3)-Receptor Antagonist KB-R6933 on Experimental Diarrhea Models
- Effects of the 5-hydroxytrypyamine3 (5-HT3)-receptor antagonist KB-R6933 on experimental diarrhea models
この論文をさがす
抄録
The effects of a 5-hydroxytryptamine3 (5-HT3)-receptor antagonist KB-R6933 (6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)-benzimidazole dimaleate) on experimental diarrhea and on intestinal fluid secretion stimulated by cholera toxin were examined and compared with those of ramosetron and loperamide. KB-R6933 and ramosetron (0.03 - 1 mg/kg, p.o.) inhibited the diarrhea induced by 5-HT, but not that by castor oil or prostaglandin E2 (PGE2), in mice. Loperamide significantly inhibited the diarrhea induced by 5-HT, castor oil and PGE2. All drugs tested inhibited the diarrhea induced by restraint stress and the intestinal fluid secretion stimulated by cholera toxin in rats. The results suggest the possibility that KB-R6933 may have clinical efficacy in the treatment of diarrhea.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 80 (1), 93-96, 1999
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204285091712
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- NII論文ID
- 10008194728
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXjtlGis7Y%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 4733209
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- PubMed
- 10446763
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4733209
- https://api.elsevier.com/content/article/PII:S0021519819308959?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819308959?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/80/1/80_1_93/_pdf
- https://search.jamas.or.jp/link/ui/1999233743
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可