Effect of the 5-Hydroxytryptamine3 (5-HT3)-Receptor Antagonist KB-R6933 on Exerimental Diarrhea Models.

• Ozaki Akio

  Pharmaceuticals R&D Center, Kanebo, Ltd.

• Yoshidomi Mikio

  Pharmaceuticals R&D Center, Kanebo, Ltd.

• Sukamoto Takayuki

  Pharmaceuticals R&D Center, Kanebo, Ltd.

Bibliographic Information

Other Title

• Effect of the 5-Hydroxytryptamine3(5-HT3)-Receptor Antagonist KB-R6933 0n Experimental Diarrhea Models
• Effect of the 5 Hydroxytryptamine3 5 HT3 Receptor Antagonist KB-R6933 0n Experimental
• Effect of the 5-Hydroxytryptamine3 (5-HT3)-Receptor Antagonist KB-R6933 on Experimental Diarrhea Models
• Effects of the 5-hydroxytrypyamine3 (5-HT3)-receptor antagonist KB-R6933 on experimental diarrhea models

Abstract

The effects of a 5-hydroxytryptamine₃ (5-HT₃)-receptor antagonist KB-R6933 (6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)-benzimidazole dimaleate) on experimental diarrhea and on intestinal fluid secretion stimulated by cholera toxin were examined and compared with those of ramosetron and loperamide. KB-R6933 and ramosetron (0.03 - 1 mg/kg, p.o.) inhibited the diarrhea induced by 5-HT, but not that by castor oil or prostaglandin E₂ (PGE₂), in mice. Loperamide significantly inhibited the diarrhea induced by 5-HT, castor oil and PGE₂. All drugs tested inhibited the diarrhea induced by restraint stress and the intestinal fluid secretion stimulated by cholera toxin in rats. The results suggest the possibility that KB-R6933 may have clinical efficacy in the treatment of diarrhea.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 80 (1), 93-96, 1999

  The Japanese Pharmacological Society

Keywords

• KB-R6933
• 5-HT<SUB>3</SUB> receptor antagonist
• Diarrhea

Details

• CRID: 1390001204285091712
• NII Article ID: 10008194728
• NII Book ID: AA00691188
• DOI: 10.1254/jjp.80.93
• COI: 1:CAS:528:DyaK1MXjtlGis7Y%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL BIB ID: 4733209
• PubMed: 10446763
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4733209
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819308959?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819308959?httpAccept=text/plain
• Web Site: https://www.jstage.jst.go.jp/article/jjp/80/1/80_1_93/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999233743
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed