Chronotropic, Inotropic, Dromotropic and Coronary Vasodilator Effects of Bisaramil, a New Class I Antiarrhythmic Drug, Assessed Using Canine Isolated, Blood-Perfused Heart Preparations

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抄録

The cardiovascular effects of a new class I antiarrhythmic drug, bisaramil, were examined using canine isolated, blood-perfused heart preparations. Bisaramil exerted negative chronotropic, inotropic and dromotropic effects as well as coronary vasodilator action, which are qualitatively the same as those of classical class I drugs. The selectivity of bisaramil for the intraventricular conduction vs the other cardiac variables was compared with that of disopyramide and flecainide. Bisaramil was the most selective for intraventricular conduction, while it was the least selective for ventricular muscle contraction. We conclude that bisaramil may become a useful antiarrhythmic drug with less cardiac adverse effects.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 80(3), 267-270, 1999-07

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008195458
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4806343
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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