Enhancement of the Serotonin-Mediated Acetylcholine Release by Repeated Desmethylimipramine Treatment in the Hippocampus of Freely Moving Rats.
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- Fujii Takeshi
- Department of Pharmacology, Kyoritsu College of Pharmacy
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- Ohba Shigeru
- Department of Pharmacology, Kyoritsu College of Pharmacy
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- Nakai Katsuhiko
- Department of Pharmacology, Kyoritsu College of Pharmacy
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- Fujimoto Kazuko
- Department of Pharmacology, Kyoritsu College of Pharmacy
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- Suzuki Takeshi
- Department of Pharmacology, Kyoritsu College of Pharmacy
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- Kawashima Koichiro
- Department of Pharmacology, Kyoritsu College of Pharmacy
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Abstract
A possible involvement of serotonin-mediated cholinergic activation in the antidepressant effect of desmethylimipramine (DMI) was investigated by determination of the effects of a single or repeated DMI administration on acetylcholine (ACh) release in the hippocampus using an in vivo microdialysis technique and a radioimmunoassay for ACh. Rats were administered DMI (10 mg/kg, i.p.) acutely or repeatedly for 21 days. A single or repeated DMI administration did not cause any significant effects on the basal ACh release compared with the respective controls. Atropine perfusion in the acutely DMI-treated or control rats increased the ACh release to the same degree. In repeatedly DMI-treated rats, serotonin (5-HT) (1 to 10 μM) perfusion enhanced significantly the ACh release. However, 5-HT in acutely DMI-treated rats enhanced significantly the ACh release only at 10 μM. 5-HT did not cause any changes in ACh release in control rats. Hippocampal 5-HT content of acutely DMI-treated rats was significantly higher than that of saline-treated control rats, while no difference was observed between the repeatedly DMI- and saline-treated rats. These findings suggest, for the first time, that DMI induced a facilitation of cholinergic neurotransmission in the rat hippocampus through the activation of 5-HT-receptor function.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 80 (4), 303-309, 1999
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001204284851072
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- NII Article ID
- 10008195652
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXlslWlt74%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4836973
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- PubMed
- 10496330
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4836973
- https://api.elsevier.com/content/article/PII:S002151981930825X?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S002151981930825X?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/80/4/80_4_303/_pdf
- https://search.jamas.or.jp/link/ui/2000023506
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed