Cross Desensitizations on Contractions by P2-Agonists of Guinea Pig Ileum.
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- Sato Chiemi
- Research Laboratory of Biodynamics, School of Medicine, Fukuoka University
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- Tsujioka Yasumi
- Department of Pharmacology, School of Medicine, Fukuoka University
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- Katsuragi Takeshi
- Department of Pharmacology, School of Medicine, Fukuoka University
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The present study was designed to clarify the characteristics of contractions of guinea pig ileal longitudinal muscles evoked by α, β-methylene ATP as compared with those by other P2-agonists. α, β-Methylene ATP, ADP-β-S and 2-methylthio ATP as P2-agonists produced remarkable phasic contractions of the segment in a suramin-sensitive- and reactive blue-2-insensitive manner. However, ADP-β-S and 2-methylthio ATP, unlike α, β-methylene ATP, showed a biphasic contraction accompanied by a second sustained phase. Their second sustained contractions were notably suppressed by 30 μM reactive blue-2, probably being a component mediated by P2Y-purinoceptor. The phasic contractile response to α, β-methylene ATP, but not ADP-β-S and 2-methylthio ATP, was largely reduced by tetrodotoxin and atropine, indicating that the contraction is due to acetylcholine released from the cholinergic nerves. At 100 μM, α, β-methylene ATP inhibited the phasic contractions caused by a low concentration of itself, but not those induced by ADP-β-S and 2-methylthio ATP, presumably serving as a desensitizer of the P2-receptor. Although β, γ-methylene ATP per se showed little contraction, it prevented the contraction evoked by α, β-methylene ATP, but not those by ADP-β-S and 2-methylthio ATP. The contraction evoked by 100 μM 2-methylthio ATP was attenuated in the presence of ADP-β-S at 10 and 30 μM. From separate cross-interactions between two groups of P2-agonists, there seems to be different subtypes of P2X-purinoceptors in the pre- and postsynapse in producing phasic contractions, but not sustained contractions that are mediated by, presumably, the P2Y-purinoceptor of the ileum.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 80 (4), 311-317, 1999
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679261561856
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- NII論文ID
- 10008195690
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXlslWlt78%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 4836982
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- PubMed
- 10496331
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4836982
- https://api.elsevier.com/content/article/PII:S0021519819308261?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819308261?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/80/4/80_4_311/_pdf
- https://search.jamas.or.jp/link/ui/2000030206
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- 本文言語コード
- en
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- JaLC
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