Monitoring of Radical Scavenging Activity of Peroral Administration of the Kampo Medicine Sho-saiko-to in Rats

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The <I>Kampo</I> medicine <I>Sho-saiko-to</I> scavenged superoxide anion radicals (O<SUB>2</SUB><SUP>-</SUP>), hydroxyl radicals (·OH) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radicals in a dose-dependent fashion. We attempted to investigate the transition of free radical scavenging activity in plasma after oral administration of <I>Sho-saiko-to</I> in rats. From the response-time profile, kinetic parameters including values for K<SUB>a</SUB> (absorption rate constant), T<SUB>max</SUB> (peak concentration time), T<SUB>1/2</SUB> (half life) and MRT (mean residence time) of radical scavenging activity in plasma could be calculated for the O<SUB>2</SUB><SUP>-</SUP>, ·OH and DPPH radicals. These parameters calculated from the dynamics of antioxidation are considered a very meaningful procedure to examine the effects of <I>Sho-saiko-to</I>.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 80(4), 379-382, 1999-08-01

    The Japanese Pharmacological Society

参考文献:  14件中 1-14件 を表示

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各種コード

  • NII論文ID(NAID)
    10008195946
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4837059
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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