Monitoring of Radical Scavenging Activity of Peroral Administration of the Kampo Medicine Sho-saiko-to in Rats.

• Egashira Toru

  Department of Pharmacology, Oita Medical University

• Takayama Fusako

  Department of Pharmacology, Oita Medical University

• Yamanaka Yasumitsu

  Department of Pharmacology, Oita Medical University

• Komatsu Yasuhiro

  Kampo and Pharmacognosy Laboratories, Tsumura & Co.

Bibliographic Information

Other Title

• Monitorning of Radical Scavenging Activity of Peroral Administration of the Kampo Medicine Sho-saiko-to in Rats
• Monitoring of radical scavenging ability of peroral administration of Kampo medicine Sho-saiko-to in rats

Abstract

The Kampo medicine Sho-saiko-to scavenged superoxide anion radicals (O₂^-), hydroxyl radicals (·OH) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radicals in a dose-dependent fashion. We attempted to investigate the transition of free radical scavenging activity in plasma after oral administration of Sho-saiko-to in rats. From the response-time profile, kinetic parameters including values for K_a (absorption rate constant), T_max (peak concentration time), T_1/2 (half life) and MRT (mean residence time) of radical scavenging activity in plasma could be calculated for the O₂^-, ·OH and DPPH radicals. These parameters calculated from the dynamics of antioxidation are considered a very meaningful procedure to examine the effects of Sho-saiko-to.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 80 (4), 379-382, 1999

  The Japanese Pharmacological Society

Keywords

• <I>Sho-saiko-to</I> (<I>Kampo</I> medicine)
• Radical scavenger
• Pharmacodynamics

Details

• CRID: 1390001204284876672
• NII Article ID: 10008195946
• NII Book ID: AA00691188
• DOI: 10.1254/jjp.80.379
• COI: 1:CAS:528:DyaK1MXlslWltL4%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL BIB ID: 4837059
• PubMed: 10496340
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4837059
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819308352?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819308352?httpAccept=text/plain
• Web Site: https://www.jstage.jst.go.jp/article/jjp/80/4/80_4_379/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000045345
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed