Antinociceptive Effect of R-(+)-Hyoscyamine on the Conjunctival Reflex Test in Rabbits

この論文にアクセスする

この論文をさがす

著者

抄録

<I>R</I>-(+)-Hyoscyamine (1 - 10 μg/kg, s.c.) dose-dependently increased the local anesthetic effect of procaine (50 μg/ml) and lidocaine (50 μg/ml) in the conjunctival reflex test in the rabbit. This potentiating effect is completely prevented by the M<SUB>1</SUB> antagonist dicyclomine (10 mg/kg, s.c.). The intensity of <I>R</I>-(+)-hyoscyamine antinociception was comparable to that induced by morphine (2 mg/kg, s.c.) and minaprine (15 mg/kg, s.c.), used as analgesic reference drugs. In the same experimental conditions, the <I>S</I>-(-)-enantiomer of atropine (0.1 - 10 μg/kg, s.c.), was completely ineffective. The present results confirm the ability of <I>R</I>-(+)-hyoscyamine to produce a paradoxical antinociceptive effect mediated by a cholinergic mechanism not only in rodents but also in the rabbit.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 81(1), 34-37, 1999-09

    The Japanese Pharmacological Society

参考文献:  11件中 1-11件 を表示

各種コード

  • NII論文ID(NAID)
    10008196099
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4867787
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ