Diazepam Increases Calcium Sensitivity of the Skinned Cardiac Muscle Fiber in Guinea Pig

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著者

    • Hara Yukio HARA Yukio
    • Department of Veterinary Pharmacology. School of Veterinary Medicine and Animal Sciences, Kitasato University
    • NISHINO Takeshi
    • Department of Veterinary Pharmacology. School of Veterinary Medicine and Animal Sciences, Kitasato University
    • KONDO Hiroshi
    • Department of Veterinary Pharmacology. School of Veterinary Medicine and Animal Sciences, Kitasato University

抄録

Influences of diazepam, a benzodiazepine derivative, on the contractile response to calcium in skinned trabecular fibers of guinea pig heart were examined. Diazepam (100 μM) enhanced the contractile response of the skinned fiber to calcium and shifted the concentration-response curve to the left. The pCa<SUB>50</SUB> values were 6.07±0.03 and 6.28±0.03 (P<0.05) in the absence and presence of diazepam, respectively. This result suggests that diazepam increases calcium sensitivity of contractile proteins in heart muscles.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 81(1), 122-124, 1999-09

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008196402
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4867945
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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