Maitotoxin-Induced Phosphoinositide Hydrolysis Is Dependent on Extracellular but Not Intracellular Ca^<2+> in Human Astrocytoma Cells

この論文にアクセスする

この論文をさがす

著者

抄録

Since maitotoxin, a potent marine toxin, is known to cause not only Ca<SUP>2+</SUP> influx but also phosphoinositide hydrolysis, we investigated the Ca<SUP>2+</SUP> dependency of maitotoxin-induced phosphoinositide hydrolysis in 1321N1 human astrocytoma cells. Maitotoxin elicited inositol 1, 4, 5-trisphosphate accumulation in a time-dependent manner. In [<SUP>3</SUP>H]inositol-labeled cells, maitotoxin stimulated phosphoinositide hydrolysis in an extracellular Ca<SUP>2+</SUP>-dependent manner. Maitotoxin also caused an intracellular Ca<SUP>2+</SUP> elevation, which was abolished by an intracellular Ca<SUP>2+</SUP> chelater BAPTA-AM. Interestingly, maitotoxin still caused phosphoinositide hydrolysis in the BAPTA-AM-treated cells. These results indicate that maitotoxin-induced phosphoinositide hydrolysis is dependent on extracellular but not intracellular Ca<SUP>2+</SUP> in 1321N1 human astrocytoma cells.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 81(2), 240-243, 1999-10

    The Japanese Pharmacological Society

参考文献:  15件中 1-15件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008197056
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    JPN
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4886740
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
ページトップへ