Protective Effect of KB-R7943, a Novel Na^+/Ca^<2+> Exchange Inhibitor, on Ischemic Acute Renal Failure in Rats

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The effects of KB-R7943 (2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulfonate), a novel Na<SUP>+</SUP>/Ca<SUP>2+</SUP> exchange inhibitor, on ischemic acute renal failure (ARF) in rats were examined. ARF was induced by clamping the left renal pedicle for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal function was markedly diminished in ARF rats. Pretreatment with KB-R7943 (10 mg/kg, i.v.) markedly attenuated the ARF-induced renal dysfunction. Histopathological examination of the kidney of ARF rats revealed severe renal damage, which was suppressed by KB-R7943. Activation of the reverse mode of Na<SUP>+</SUP>/Ca<SUP>2+</SUP> exchange seems to play an important role in the pathogenesis of ARF. A selective Na<SUP>+</SUP>/Ca<SUP>2+</SUP> exchange inhibitor may be useful in cases of ARF.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 81(2), 247-251, 1999-10

    The Japanese Pharmacological Society

参考文献:  15件中 1-15件 を表示

被引用文献:  4件中 1-4件 を表示

各種コード

  • NII論文ID(NAID)
    10008197088
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4886750
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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