Role of the Angiotensin II Type-2 Receptor in the Mouse Central Nervous System

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There are two known major angiotensin II receptor subtypes, type 1 (AT<SUB>1</SUB>) and type 2 (AT<SUB>2</SUB>), both of which are present in the brain. AT<SUB>1</SUB> and AT<SUB>2</SUB> receptors occur in characteristic distributions that are highly correlated with the distribution of angiotensin II-like immunoreactivity in nerve terminals. Acting through the AT<SUB>1</SUB> receptor in the central nervous system, angiotensin II has effects on fluid and electrolyte homeostasis, neuroendocrine systems, autonomic pathways regulating cardiovascular function and behavior. While the role of the AT<SUB>2</SUB> receptor in the brain is less well understood, recent knockout studies point to their involvement in behavioral and cardiovascular functions. We discuss here evidence regarding the function of the AT<SUB>2</SUB> receptor in the brain, determined using mice lacking the AT<SUB>2</SUB> receptor.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 81(3), 259-263, 1999-11

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008197145
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00215198
  • NDL 記事登録ID
    4918231
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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