Effects of Toluene on Regulation of Adenylyl Cyclase by Stimulation of G-Protein-Coupled Receptors Expressed in CHO Cells

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抄録

We determined the effects of toluene exposure on activation or inhibition of adenylyl cyclase by stimulating human β<SUB>2</SUB>-adrenergic receptors (β<SUB>2</SUB>-AR) and muscarinic acetylcholine receptor (mAChR) m2 subtypes, respectively, expressed in CHO cells. The formation of cAMP via β<SUB>2</SUB>-AR stimulation was slightly but not significantly facilitated in the presence of 3.7 μM toluene. On the other hand, the inhibition of adenylyl cyclase by 10 μM of carbamylcholine stimulation of mAChR m2 subtypes was attenuated in the presence of toluene. These results strongly suggest that toluene affects activation of G<SUB>i</SUB> rather than G<SUB>s</SUB>.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 81(3), 305-308, 1999-11

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008197350
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4918395
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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