On the Inotropic Actions of Arginine Vasopressin in Ventricular Muscle of the Guinea Pig Heart

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Arginine vasopressin (AVP) (0.03 - 3 μM) produced transient negative responses that were followed by slowly developing positive inotropic responses in guinea pig papillary muscles. The inotropic responses were antagonized by OPC-21268 (10 μM), but not by OPC-31260, and suppressed by neomycin (3 mM). The negative inotropic response was hardly affected by staurosporine (10 nM) and H-7 (10 μM). AVP (1 μM) elicited a transient decrease followed by a slowly developing increase in I<SUB>Ca</SUB>. The latter increase in I<SUB>Ca</SUB> was not elicited in the presence of staurosporine (1 nM). These results indicate that AVP stimulates V1 receptors that couple to phosphoinositide hydrolysis and thereby increases intracellular Ca<SUP>2+</SUP> and activates protein kinase C.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 81(3), 309-312, 1999-11

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008197366
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4918420
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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