Antagonistic Effect of N-Methyltyramine on .ALPHA.2-Adrenoceptor in Mice.

• Koda Hirofumi

  Products Safety & Alcohol Science Laboratory, Suntory Limited

• Yokoo Yoshiaki

  Technical Development Department, Suntory Limited

• Matsumoto Nobuya

  Technical Development Department, Suntory Limited

• Suwa Yoshihide

  Products Safety & Alcohol Science Laboratory, Suntory Limited

• Fukazawa Hirotatsu

  Department of Medicinal Chemistry of Natural Product, School of Pharmaceutical Science, University of Shizuoka

• Ishida Hitoshi

  Department of Medicinal Chemistry of Natural Product, School of Pharmaceutical Science, University of Shizuoka

• Tsuji Kuniro

  Department of Medicinal Chemistry of Natural Product, School of Pharmaceutical Science, University of Shizuoka

• Nukaya Haruo

  Department of Medicinal Chemistry of Natural Product, School of Pharmaceutical Science, University of Shizuoka

• Kuriyama Kinya

  Kyoto Prefectural University of Medicine

Bibliographic Information

Other Title

• Antagonistic Effect of N-Methyltyramine on α2-Adrenoceptor in Mice
• Antagonistic Effect of N-Methyltyramine on アルファ2-Adrenoceptor in Mice

Abstract

We examined the effect of N-methyltyramine (NMT) on α₂-adrenoceptor. NMT (10^-8 - 10^-3 M) inhibited the binding of [³H]p-aminoclonidine to α₂-adrenoceptor dose-dependently. However, the IC₅₀ value for NMT (5.53×10^-6 M) was higher than that for RX821002, an α₂-adrenoceptor antagonist (1.07×10^-8 M). RX821002 (5 mg/kg, i.p.) inhibited hypermotility induced by scopolamine (8 mg/kg, s.c.) in male ddY mice. NMT (20 or 100 mg/kg, i.p.) was found to have a dose-dependent inhibitory effect similar to that of RX821002. These findings indicate that NMT has the properties of an α₂-adrenoceptor antagonist. However, the affinity of NMT for α₂-adrenoceptor is weaker than that of RX821002.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 81 (3), 313-315, 1999

  The Japanese Pharmacological Society

Keywords

• <I>N</I>-Methyltyramine
• α<SUB>2</SUB>-Adrenoceptor
• Scopolamine

Details

• CRID: 1390001204285634816
• NII Article ID: 10008197382
• NII Book ID: AA00691188
• DOI: 10.1254/jjp.81.313
• COI: 1:CAS:528:DyaK1MXns1Gntbo%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL BIB ID: 4918446
• PubMed: 10622222
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4918446
• Web Site: https://www.jstage.jst.go.jp/article/jjp/81/3/81_3_313/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000070548
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed