新規抗潰よう剤Ｔ‐５９３の体内動態　（第２報）　　ラットにおける胎児および乳汁移行性

• 小野田 誠

  富山化学工業株式会社綜合研究所

• 門田 卓美

  富山化学工業株式会社綜合研究所

• 大山 進祐

  富山化学工業株式会社綜合研究所

• 松谷 博子

  富山化学工業株式会社綜合研究所

• 酒井 広志

  富山化学工業株式会社綜合研究所

• 今泉 弘之

  富山化学工業株式会社綜合研究所

• 中島 良文

  富山化学工業株式会社綜合研究所

書誌事項

タイトル別名

• Metabolic Fate of a Novel Antiulcer Agent, T-593. (II). Transfer into Fetus and Milk in Rats.

抄録

The transfer of radioactivity into the fetus and milk after oral administration of ¹⁴C-T-593 at a dose of 10 mg/kg were investigated in pregnant and lactating rats.<BR> 1. The levels of radioactivity in the whole fetus and fetal tissues at 2 hr, after oral administration of ¹⁴CT-593 at a dose of 10 mg/kg to fasting pregnant rats on 19th day of gestation, accounted for less than 16.8% of that in the maternal plasma. The radioactivity in the fetal tissues was eliminated slowly when compared with the elimination from the maternal tissues.<BR> 2. The whole body autoradiograms, after oral administration of ¹⁴C-T-593 at a dose of 10 mg/kg to fasting pregnant rats on 12th and 19th day of gestation, showed that radioactivity was scarcely noted in the fetus.<BR> 3. The levels of radioactivity in the milk, after oral administration of ¹⁴C-T-593 at a dose of 10 mg/kg to non-fasting lactating rats, reached the C_max at 6 hr and was 2.4 times higher than that in the plasma. The levels in milk decreased in parallel with that in plasma.

収録刊行物

• 薬物動態

  薬物動態 13 (5), 449-458, 1998

  日本薬物動態学会

キーワード

• T-593
• Antiulcer agent
• Transfer into fetus
• Transfer into milk
• Distribution
• Oral administration
• Rats

詳細情報

• CRID: 1390001204668356224
• NII論文ID: 10008198889
• NII書誌ID: AN10144117
• DOI: 10.2133/dmpk.13.449
• ISSN: 09161139
• Web Site: http://www.jstage.jst.go.jp/article/dmpk1986/13/5/13_5_449/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999089158
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可