鎮痛作用に関わる活性モルヒネグルクロナイドをめぐって An Active Morphine Glucuronide Responsible for Morphine Analgesia

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抄録

Since the discovery of morphine-6-glucuronide over three decades ago, an increasing body of work has emerged supporting the concept of an active metabolite in experimental animals and humans. Pharmacological characterization with antisense oligodeoxynucleotide of mu-opioid receptor, MOR-1 and receptor binding study have suggested the existence of an unique receptor of mu-subtype for morphine-6-glucuronide. In this review, our studies on species difference of site selective glucuronidation of morphine and UDP-glucuronosyltransferases responsible for the glucuronidation were presented. Recent experimental evidence supporting the view that UDP-glucuronosyltransferase isoforms could act as hetero-oligomers by accessing a broader range of substrates is included.

収録刊行物

  • 薬物動態 = Xenobiotic metabolism and disposition

    薬物動態 = Xenobiotic metabolism and disposition 14(5), 399-403, 1999-10-29

    The Japanese Society for the Study of Xenobiotics

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各種コード

  • NII論文ID(NAID)
    10008199815
  • NII書誌ID(NCID)
    AN10144117
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    09161139
  • データ提供元
    CJP書誌  J-STAGE 
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