An Active Morphine Glucuronide Responsible for Morphine Analgesia.

• OGURI Kazuta

  Graduate School of Pharmaceutical Sciences, Kyushu University

Bibliographic Information

Other Title

• 鎮痛作用に関わる活性モルヒネグルクロナイドをめぐって

Abstract

Since the discovery of morphine-6-glucuronide over three decades ago, an increasing body of work has emerged supporting the concept of an active metabolite in experimental animals and humans. Pharmacological characterization with antisense oligodeoxynucleotide of mu-opioid receptor, MOR-1 and receptor binding study have suggested the existence of an unique receptor of mu-subtype for morphine-6-glucuronide. In this review, our studies on species difference of site selective glucuronidation of morphine and UDP-glucuronosyltransferases responsible for the glucuronidation were presented. Recent experimental evidence supporting the view that UDP-glucuronosyltransferase isoforms could act as hetero-oligomers by accessing a broader range of substrates is included.

Journal

• Drug Metabolism and Pharmacokinetics

  Drug Metabolism and Pharmacokinetics 14 (5), 399-403, 1999

  The Japanese Society for the Study of Xenobiotics

Keywords

• Morphine
• Morphine glucuronide
• Active metabolite
• UDP-glucuronosyltransferase

Details

• CRID: 1390001204670219008
• NII Article ID: 10008199815
• NII Book ID: AN10144117
• DOI: 10.2133/dmpk.14.399
• ISSN: 09161139
• Web Site: http://www.jstage.jst.go.jp/article/dmpk1986/14/5/14_5_399/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000095764
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed