エリスリトールの発酵生産技術の開発とその利用 Development of Erythritol Fermentation and Its Applications

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Erythritol, a tetra-carbon sugar alcohol (1, 2, 3, 4-butanetetrol, MW: 122.12) is distributed widely in nature. It is found in lichens, mushrooms, fruits, animal semen, lens, and some fermented foods such as wine, Japanese sake, or soy sauce as one of the microbial metabolites. This means that hu-mans have been consuming it unconsciously from ancient times. We tried to establish the mass-production of erythritol by fermentation in order to clarify chemical, physical, and physiological properties that were still unknown, and also to develop its utilization as a food material, as well as an ingredient for chemicals, pharmaceuticals and medicines. Microorganisms having the ability to produce polyols at high yield were screened and isolated from various natural sources by using cul-ture media containing a high glucose concentration. Among them, a few strains were selected as erythritol-producing microorganisms. Some undesirable properties of wild strain, especially insuffi-cient osmo-tolerance in media and vigorous foaming under aerobic culturing conditions were im-proved by UV irradiation and mutagen treatment. Using the mutant strains obtained, large-scale fer-mentation in a reactor tank was tested mainly from the view point of cost reduction. Satisfactory results were obtained in terms of erythritol yield, decrease of coloring materials and by-products, and also aeration conditions. As a consequence, we achieved a manufacturing technology for highly efficient production of erythritol from glucose as a substrate by fermentative process. Since the mass supply of erythritol became possible, its characteristics have been rapidly investigated and clarified. Erythritol is a fine crystal with a sweetness level 75-80% of sugar, heat-stable and less-hygroscopic. It is an extremely low calory sweetner, with an energy value estimated as 0.2 kcal/g. The FDA accepted the application of erythritol as a GRAS material in 1997, and also, the JECFA recognized it as the safest substance, ADI not specified, in 1999. Nikken Chemical Co., Ltd. (part-ner of this research project) launched the commercial production of erythritol and plans to intro-duce industrial uses in the future.

収録刊行物

  • 応用糖質科学 : oyo toshitsu kagaku = Journal of applied glycoscience

    応用糖質科学 : oyo toshitsu kagaku = Journal of applied glycoscience 47(1), 117-124, 2000-03-31

    The Japanese Society of Applied Glycoscience

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各種コード

  • NII論文ID(NAID)
    10008251651
  • NII書誌ID(NCID)
    AN10453916
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    13403494
  • NDL 記事登録ID
    5397275
  • NDL 雑誌分類
    ZP24(科学技術--化学・化学工業--糖・澱粉)
  • NDL 請求記号
    Z17-15
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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