Gene Organization in a 12-Kilobase Region Covering afsA Encoding an A-Factor Biosynthetic Enzyme

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The nucleotide sequence of a 12-kilobase region covering <I>afsA</I> encoding a key enzyme for A- factor biosynthesis in <I>Streptomyces griseus</I> was determined and open reading frames were deduced by means of G+C plot analysis. Although this region about 150-kb from one end of the linear chromosome is known to be readily deleted, open reading frames crowd the region in a total of eleven, including <I>afsA</I> and <I>sgaA</I> involved in healthy growth on medium of high osmolality. These also include a pair of a sensor histidine kinase and a regulator which comprises a typical prokaryotic two-component regulatory system, proteins similar to <I>O</I>-methyltransferase, LysR-type regulator, 3-ketoacyl-acyl carrier protein reductase, and NADP-dependent alcohol dehydrogenase. In contrast to <I>afsA</I>-like genes in other <I>Streptomyces</I> strains, such as <I>barX</I> locating closely to the gene for the virginiae butanolide receptor in <I>Streptomyces virginiae</I> and <I>farX</I> locating closely to the IM-2-receptor gene in a <I>Streptomyces</I> sp., no open reading frames in this region in <I>S. griseus</I> show homology with the A-factor receptor protein, which suggests that the gene organization of receptor genes for γ-butyrolactone autoregulators differs from strain to strain.

収録刊行物

  • 日本放線菌学会誌

    日本放線菌学会誌 12(1), 40-45, 1998-06-30

    The Society for Actinomycetes Japan

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各種コード

  • NII論文ID(NAID)
    10008262861
  • NII書誌ID(NCID)
    AN10080091
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    09145818
  • NDL 記事登録ID
    4524026
  • NDL 雑誌分類
    ZR5(科学技術--生物学--菌類・微生物)
  • NDL 請求記号
    Z18-1070
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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