Expression of Dissolution Rate Applicable to Wide Range of Particle Sizes

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  • 広範囲の粒径に適用可能な溶解速度表示法
  • コウハンイ ノ リュウケイ ニ テキヨウ カノウ ナ ヨウカイ ソクド ヒョウジホウ

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Abstract

A method to measure the dissolution rate of salt that can be applied to a wide range of particle sizes, and that can be used to compare values using different types of equipment and dissolution conditions, was developed. The problem with the present column method was clarified. On the other hand, using the agitation method, the measured value that suits the dissolution theory was obtained under dissolution conditions in which all particles float. Moreover, using the relative dissolution rate calculated for a cubic standard sample with a uniform particle size, a comparison of the values measured using different types of equipment and dissolution conditions was carried out.

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