Effective Arterial Elastance of Irregular Beats during Atrial Fibrillation in Canine Left Ventricle.

• Mitani Hidenobu

  Department of Cardiovascular Surgery, Okayama University Medical School

• Yamaguchi Hiroki

• Morita Terumasa

• Oshima Yu

• Shimizu Juichiro

• Ito Haruo

• Araki Junichi

• Takaki Miyako

• Sano Shunji

• Suga Hiroyuki

抄録

Effective arterial elastance (E_a) was originally defined as the end-systolic pressure (ESP)/stroke volume (SV) ratio of the left ventricle (LV). E_a combined with LV contractility (E_max), E_a/E_max, proved to be powerful in analyzing the ventriculo-arterial coupling of normal and failing hearts in regular beats. However, E_a sensitively changes with LV E_max, preload, and afterload widely changing among irregular beats. This has discouraged the use of E_a during arrhythmia. However, we hypothesized that E_a could serve as the effective afterload (not always arterial) elastance against ventricular ejection under arrhythmia. We tested this hypothesis by analyzing beat-to-beat changes in E_a of irregular beats during electrically induced atrial fibrillation (AF) in normal canine in situ hearts. We newly found that during AF in each heart: 1) E_a changed widely among irregular beats and became markedly high in weak beats with small SVs; 2) E_a and E_a/E_max distributed non-normally with large skewness but 1/E_a distributed more normally; 3) 1/E_a correlated closely with end-diastolic volume, E_max and preceding beat intervals; and 4) the reciprocal of mean 1/E_a closely correlated with mean ESP/mean SV. These results support our hypothesis that E_a can serve as the effective afterload elastance against ventricular ejection on a per-beat basis during AF. E_a/E_max can also quantify the ventriculo-afterload (not arterial) coupling on a per-beat basis. This study, however, warns that mean E_a and mean E_a/E_max of irregular beats cannot necessarily represent their averages during AF.<br>

収録刊行物

• The Japanese Journal of Physiology

  The Japanese Journal of Physiology 50 (1), 77-89, 2000

  一般社団法人　日本生理学会

キーワード

• effective afterload elastance
• ventriculo-afterload coupling
• ventricular afterload
• arrhythmia
• cardiac mechanoenergetics

詳細情報

• CRID: 1390001205042910592
• NII論文ID: 130004435712
• NII論文ID: 30015529782
• NII論文ID: 10008290482
• NII書誌ID: AA00691224
• DOI: 10.2170/jjphysiol.50.77
• COI: 1:STN:280:DC%2BD3czisFOhsg%3D%3D
• ISSN: 18811396
• ISSN: 0021521X
• NDL書誌ID: 5411026
• PubMed: 10866700
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5411026
• Web Site: https://search.jamas.or.jp/link/ui/2001021398
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可