Involvement of Ca^<2+> in Antiarrhythmic Effect of Ischemic Preconditioning in Isolated Rat Heart

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We investigated the relationship between the effects of ischemic preconditioning (IPC) and Ca<sup>2+</sup> preconditioning (CPC) on reperfusion-induced arrhythmias. In the control group (noPC), Langendorff-perfused rat hearts were subjected to 5-min zero-flow global ischemia (I) followed by 15-min reperfusion (I/R). In ischemic preconditioning groups (IPC), the hearts were subjected to three cycles of 3-min global ischemia and 5-min reperfusion. In the CPC group, the hearts were exposed to three cycles of 3-min perfusion of higher Ca<sup>2+</sup> (2.3 mmol/l Ca<sup>2+</sup>) followed by 5-min perfusion of normal 1.3 mmol/l Ca<sup>2+</sup>, and the hearts were then subjected to I/R. Verapamil was administered in several hearts of the IPC group (VR+IPC). Ventricular arrhythmias upon reperfusion were less frequently seen in the IPC and CPC groups than in the noPC and VR+IPC groups. IPC and CPC could attenuate conduction delay and enhance shortening of the monophasic action potential duration during ischemia. The ventricular fibrillation threshold measured at 1-min reperfusion was significantly higher in the IPC and CPC groups than in the noPC and VR+IPC groups. Verapamil completely abolished the salutary effects of IPC. These results demonstrate that Ca<sup>2+</sup> plays an important role in the antiarrhythmic effect of IPC during reperfusion.<br>

収録刊行物

  • The Japanese journal of physiology

    The Japanese journal of physiology 50(2), 207-213, 2000-04

    PHYSIOLOGICAL SOCIETY OF JAPAN

参考文献:  22件中 1-22件 を表示

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各種コード

  • NII論文ID(NAID)
    10008290939
  • NII書誌ID(NCID)
    AA00691224
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    0021521X
  • NDL 記事登録ID
    5413498
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z53-D40
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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