Volume Expansion Sensitivity of Swelling-Activated Cl^- Channel in Human Epithelial Cells

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In human epithelial cell lines, whole-cell swelling-activated Cl<sup>−</sup> current was not directly correlated to cell volume per se, membrane tension or hydrostatic pressure. The current density exhibited a relation described by a Boltzmann function to the square of the cell diameter. Cytochalasin D enhanced the volume sensitivity. These results suggest that the activation mechanism of volume-sensitive Cl<sup>−</sup> channel is related to cytoskeleton-dependent membrane spring energy in human epithelial cells.<br>

収録刊行物

  • The Japanese journal of physiology

    The Japanese journal of physiology 50(2), 277-280, 2000-04

    PHYSIOLOGICAL SOCIETY OF JAPAN

参考文献:  11件中 1-11件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008291213
  • NII書誌ID(NCID)
    AA00691224
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    0021521X
  • NDL 記事登録ID
    5413563
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z53-D40
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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