Volume Expansion Sensitivity of Swelling-Activated Cl〔-〕 Channel in Human Epithelial Cells

• Morishima Shigeru

  Department of Cell Physiology, National Institute for Physiological Sciences

• Shimizu Takahiro

• Kida Hajime

• Okada Yasunobu

書誌事項

タイトル別名

• Volume Expansion Sensitivity of Swelling-Activated Cl- Channel in Human Epithelial Cells.
• Volume expansion sensitivity of swelling-activated Cl− channel in human epithelial cells

抄録

In human epithelial cell lines, whole-cell swelling-activated Cl⁻ current was not directly correlated to cell volume per se, membrane tension or hydrostatic pressure. The current density exhibited a relation described by a Boltzmann function to the square of the cell diameter. Cytochalasin D enhanced the volume sensitivity. These results suggest that the activation mechanism of volume-sensitive Cl⁻ channel is related to cytoskeleton-dependent membrane spring energy in human epithelial cells.<br>

収録刊行物

• The Japanese Journal of Physiology

  The Japanese Journal of Physiology 50 (2), 277-280, 2000

  一般社団法人　日本生理学会

キーワード

• Cl⁻ channel
• volume sensor
• cell volume regulation

詳細情報

• CRID: 1390282680017676032
• NII論文ID: 10008291213
• NII書誌ID: AA00691224
• DOI: 10.2170/jjphysiol.50.277
• COI: 1:CAS:528:DC%2BD3cXksVCqu7k%3D
• ISSN: 18811396
• ISSN: 0021521X
• NDL書誌ID: 5413563
• PubMed: 10880886
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5413563
• Web Site: https://search.jamas.or.jp/link/ui/2001023935
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可