Nitric Oxide and Thermogenic Function of Brown Adipose Tissue in Rats

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To clarify the effects of cold acclimation and immobilization stress adaptation of rats on nitric oxide (NO) activity in interscapular brown adipose tissue (BAT), we incubated neatly diced (1-mm<sup>3</sup> blocks) BAT in a metabolic chamber for respiration, measured oxygen consumption using a Clark electrode, and estimated NO release in the buffer medium by measuring nitrite plus nitrate (NO<sub>x</sub>) using the Griess method (diazotization reaction). The production of NO<sub>x</sub> in the buffer medium confirmed that BAT releases NO, as there is no other source of NO<sub>x</sub> in the system. The NO activity was observed in the basal condition and increased with noradrenaline stimulation, showing a correlation with oxygen consumption in the warm (25°C)-acclimated control rats. Cold acclimation (5°C, 5 weeks) or immobilization stress adaptation (3 h daily, 25°C, 5 weeks) caused enhanced NO activity in the basal condition in comparison with the control. We suggest that NO is involved in enhancement of the thermogenic functions of BAT in rats.<br>

収録刊行物

  • The Japanese journal of physiology

    The Japanese journal of physiology 50(3), 337-342, 2000-06

    PHYSIOLOGICAL SOCIETY OF JAPAN

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各種コード

  • NII論文ID(NAID)
    10008291548
  • NII書誌ID(NCID)
    AA00691224
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    0021521X
  • NDL 記事登録ID
    5525778
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z53-D40
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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