Mechanism of Delayed Gastric Emptying in Naturally Occurring CCK-A Receptor Gene Knockout (OLETF) Rats.
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- Ohta Minoru
- Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology
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We recently found a specific strain of rats (OLETF rats) in which CCK-A receptor gene expression is lacking because of a genetic abnormality. As delayed gastric emptying has been reported in this strain, we examined its mechanism. A liquid gastric load containing phenol red was administered using an orogastric tube into the stomach in OLETF and control (LETO) rats. The stomach was removed 0, 15, 30 and 45 min after meal ingestion and the content of phenol red was measured to estimate the rate of gastric emptying. Pretreatment of reserpine enhanced gastric emptying in both strains. A tenfold dose of reserpine was required in OLETF rats to induce a similar effect to LETO rats. The plasma noradrenalin level was significantly higher in OLETF than LETO rats. When the smooth muscle of the stomach was isolated and contraction in vitro was examined, the smooth muscle functions were not deteriorated in OLETF rats. The thickness of muscle determined by hematoxylin-eosin staining was not different between strains. It is suggested that the delayed gastric emptying in OLETF rats may be due to increased sympathetic nerve function.<br>
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 50 (4), 443-448, 2000
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680020153344
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- NII論文ID
- 130004435731
- 10008291899
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- NII書誌ID
- AA00691224
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- COI
- 1:CAS:528:DC%2BD3cXosFyhtrs%3D
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- ISSN
- 18811396
- 0021521X
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- NDL書誌ID
- 5586844
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- PubMed
- 11082543
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可