2,3-Butanedione Monoxime Suppresses Primarily Total Calcium Handling in Canine Heart

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Whether 2,3-butanedione monoxime (BDM, ≤5 mmol/l) suppresses primarily crossbridge cycling or total Ca<sup>2+</sup> handling in the blood-perfused whole heart remains controversial. Although BDM seems to suppress primarily total Ca<sup>2+</sup> handling in canine hearts, more evidence is lacking. We therefore analyzed the cardiac mechanoenergetics, namely, E<sub>max</sub> (contractility), PVA (total mechanical energy), and O<sub>2</sub> consumption of canine BDM-treated hearts by our recently developed integrative method to assess myocardial total Ca<sup>2+</sup> handling. This method additionally required the internal Ca<sup>2+</sup> recirculation fraction. We obtained this from the beat constant of the exponential decay component of the postextrasystolic potentiation. Our analysis indicated significant decreases in both internal Ca<sup>2+</sup> recirculation fraction and total Ca<sup>2+</sup> handling in the BDM-treated heart, but virtually no change in the reactivity of E<sub>max</sub> to total Ca<sup>2+</sup> handling. This result corroborates the view that BDM suppresses primarily total Ca<sup>2+</sup> handling rather than crossbridge cycling in the canine blood-perfused heart.<br>

収録刊行物

  • The Japanese journal of physiology

    The Japanese journal of physiology 50(5), 543-551, 2000-10

    PHYSIOLOGICAL SOCIETY OF JAPAN

参考文献:  28件中 1-28件 を表示

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各種コード

  • NII論文ID(NAID)
    10008292222
  • NII書誌ID(NCID)
    AA00691224
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    0021521X
  • NDL 記事登録ID
    5591342
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z53-D40
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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