2,3-Butanedione Monoxime Suppresses Primarily Total Calcium Handling in Canine Heart.

• Maesako Masaki

  Department of Physiology II, Okayama University Medical School

• Araki Junichi

• Lee Shinyu

• Doi Yumiko

• Imaoka Takeshi

• Iribe Gentaro

• Mohri Satoshi

• Hirakawa Masahisa

• Harada Mine

• Suga Hiroyuki

抄録

Whether 2,3-butanedione monoxime (BDM, ≤5 mmol/l) suppresses primarily crossbridge cycling or total Ca²⁺ handling in the blood-perfused whole heart remains controversial. Although BDM seems to suppress primarily total Ca²⁺ handling in canine hearts, more evidence is lacking. We therefore analyzed the cardiac mechanoenergetics, namely, E_max (contractility), PVA (total mechanical energy), and O₂ consumption of canine BDM-treated hearts by our recently developed integrative method to assess myocardial total Ca²⁺ handling. This method additionally required the internal Ca²⁺ recirculation fraction. We obtained this from the beat constant of the exponential decay component of the postextrasystolic potentiation. Our analysis indicated significant decreases in both internal Ca²⁺ recirculation fraction and total Ca²⁺ handling in the BDM-treated heart, but virtually no change in the reactivity of E_max to total Ca²⁺ handling. This result corroborates the view that BDM suppresses primarily total Ca²⁺ handling rather than crossbridge cycling in the canine blood-perfused heart.<br>

収録刊行物

• The Japanese Journal of Physiology

  The Japanese Journal of Physiology 50 (5), 543-551, 2000

  一般社団法人　日本生理学会

キーワード

• arrhythmia
• calcium
• contractility
• pressure
• sarcoplasmic reticulum

詳細情報

• CRID: 1390001205041760384
• NII論文ID: 10008292222
• NII論文ID: 30015529603
• NII書誌ID: AA00691224
• DOI: 10.2170/jjphysiol.50.543
• COI: 1:CAS:528:DC%2BD3cXptVejsr0%3D
• ISSN: 18811396
• ISSN: 0021521X
• NDL書誌ID: 5591342
• PubMed: 11120921
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5591342
• Web Site: https://search.jamas.or.jp/link/ui/2001071543
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可