Morphine Inhibits Resting Respiration, but It Attenuates Reflexive Respiratory Suppression in Anesthetized Cat through κ-Receptor

• Kozaki Yasuko

  Department of Neural Regulation, Research Institute of Environmental Medicine, Nagoya University

• Tadaki Eiko

• Kumazawa Takao

書誌事項

タイトル別名

• Morphine Inhibits Resting Respiration, but It Attenuates Reflexive Respiratory Suppression in Anesthetized Cat through .KAPPA.-Receptor.
• Morphine Inhibits Resting Respiration but It Attenuates Reflexive Respiratory Suppression in Anesthetized Cat through カッパ Receptor

抄録

Noxious stimulation of thin-fiber muscular afferents induces a reflexive respiratory suppression that we call "poststimulus respiratory suppression." In anesthetized, vagotomized, paralyzed, and artificially ventilated cats, morphine depressed the level of resting respiration (inhibitory effect on resting respiration) and attenuated the magnitude of the poststimulus respiratory suppression (excitatory effect on the reflexively modified respiration). These two kinds of morphine effects were antagonized by naloxone, suggesting the participation of opioid receptors. To clarify the opioid receptor subtypes responsible for these effects of morphine, three type-selective opioid antagonists—naltrindole (δ antagonist), β-funaltrexamine (μ antagonist), and Mr2266 (κ antagonist)—were tested. The morphine-induced depression in the resting respiration was antagonized by pretreatment with the κ antagonist, not with the μ or δ antagonist. Furthermore, the morphine-induced attenuation in the magnitude of the poststimulus suppression was also blocked by the κ antagonist, but not by the μ or δ antagonist. In conclusion, (1) morphine inhibits resting respiration, but it attenuates the magnitude of the poststimulus respiratory suppression; (2) both these morphine effects are mediated by κ opioid receptors. The possibility that the κ₃ receptor, one of the κ receptors subtypes, mediates the two kinds of morphine effects has been discussed.<br>

収録刊行物

• The Japanese Journal of Physiology

  The Japanese Journal of Physiology 50 (6), 615-624, 2000

  一般社団法人　日本生理学会

キーワード

• morphine
• respiration
• reflexive respiratory depression
• κ opioid receptor
• Mr2266

詳細情報

• CRID: 1390001205043448960
• NII論文ID: 10008292488
• NII書誌ID: AA00691224
• DOI: 10.2170/jjphysiol.50.615
• COI: 1:CAS:528:DC%2BD3MXisVCisro%3D
• ISSN: 18811396
• ISSN: 0021521X
• NDL書誌ID: 5706372
• PubMed: 11173557
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5706372
• Web Site: https://search.jamas.or.jp/link/ui/2001188731
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可