Protein Kinase C Inhibitors Attenuate Protective Effect of High Glucose against Hypoxic Injury in H9c2 Cardiac Cells.

• Moon Chang-Hyun

  Department of Physiology, School of Medicine, Ajou University

• Jung Yi-Sook

• Kim Min Hwa

• Park Rhan Mi

• Lee Soo Hwan

• Baik Eun Joo

抄録

In this study, we demonstrated that PKC inhibitors significantly attenuated the cardioprotective effect produced by high-glucose (22 mM) treatment for 48 h against hypoxic injury in H9c2 cardiac cells. PKC activators mimicked the cardioprotective effect of high glucose. These results suggest a possible role of PKC activation in high-glucose-induced protection.<br>

収録刊行物

• The Japanese Journal of Physiology

  The Japanese Journal of Physiology 50 (6), 645-649, 2000

  一般社団法人　日本生理学会

キーワード

• high glucose
• cardioprotection
• PKC

詳細情報

• CRID: 1390282680020145920
• NII論文ID: 10008292576
• NII論文ID: 30015529581
• NII書誌ID: AA00691224
• DOI: 10.2170/jjphysiol.50.645
• COI: 1:CAS:528:DC%2BD3MXisVCisrg%3D
• ISSN: 18811396
• ISSN: 0021521X
• NDL書誌ID: 5706408
• PubMed: 11173560
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5706408
• Web Site: https://search.jamas.or.jp/link/ui/2001188988
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可