New Calculation of Internal Ca〔2+〕 Recirculation Fraction from Alternans Decay of Postextrasystolic Potentiation

• Iribe Gentaro

  Department of Physiology II, Okayama University Medical School

• Araki Junichi

• Mohri Satoshi

• Shimizu Juichiro

• Imaoka Takeshi

• Kanmura Yuichi

• Kajiya Fumihiko

• Suga Hiroyuki

書誌事項

タイトル別名

• New Calculation of Internal Ca2+ Recirculation Fraction from Alternans Decay of Postextrasystolic Potentiation.

抄録

In our previous studies, we calculated the internal Ca²⁺ recirculation fraction (RF) after obtaining the beat decay constant (τ_e) of the monoexponential component in the postextrasystolic potentiation (PESP) of the alternans decay by curve fitting. However, this method sometimes suffers from the sensitive variation of τ_e with small noises in the measured contractilities of the 5th and 6th postextrasystolic (PES) beats in the tail of the exponential component. We now succeeded in preventing this problem by a new method to calculate RF without obtaining τ_e. The equation for the calculation in the new method expresses an alternans decay of PESP as a recurrence formula of PESP. It can calculate RF directly from the contractilities of the 1st through the 4th PES beats without any fitting procedure. To evaluate the reliability of the new method, we calculated RF from the alternans decay of PESP of the left ventricle (LV) of the canine excised cross-circulated heart preparation by both the original fitting and the new method. Although there was no significant difference in the mean value of the obtained RF between these two methods, the variance of RF was smaller with the new method than with the original method. Thus the new method proved useful and more reliable than the original fitting method.<br>

収録刊行物

• The Japanese Journal of Physiology

  The Japanese Journal of Physiology 51 (2), 143-149, 2001

  一般社団法人　日本生理学会

キーワード

• myocardial Ca²⁺
• contractility
• arrhythmia
• beat constant
• extrasystole

詳細情報

• CRID: 1390282680019571840
• NII論文ID: 130004435760
• NII論文ID: 30015529478
• NII論文ID: 10008293200
• NII書誌ID: AA00691224
• DOI: 10.2170/jjphysiol.51.143
• COI: 1:STN:280:DC%2BD3MzktleisQ%3D%3D
• ISSN: 18811396
• ISSN: 0021521X
• NDL書誌ID: 5906202
• PubMed: 11405906
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5906202
• Web Site: https://search.jamas.or.jp/link/ui/2002005906
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可