Involvement of Different Activator Ca^<2+> in the Rate-Dependent Stretch-Induced Contractions of Canine Basilar Artery

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Stretch evoked a contraction in a rate-dependent manner in canine basilar artery; slow stretch at rates less than 3 mm/s produced no active tension, whereas quick stretch at rates over 5 mm/s did. Large conductance Ca<sup>2+</sup>-activated K<sup>+</sup> channel blockers, including charybdotoxin, iberiotoxin, and tetraethylammonium (TEA) sensitized the basilar artery to mechanical stimulation. TEA shifted the stretch rate-tension relationship toward the left. Thus, in the presence of TEA, the slow stretch (0.1-3 mm/s) could increase in intracellular Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>) and active tension. The contraction in response to slow stretch (1 mm/s) was abolished by nicardipine and Gd<sup>3+</sup>. Quick stretch (100 mm/s) increased [Ca<sup>2+</sup>]<sub>i</sub> and active tension, both of which were partially inhibited by nicardipine or Gd<sup>3+</sup>. The Gd<sup>3+</sup>-insensitive component of quick stretch-induced contraction was eliminated by thapsigargin, but not by nicardipine. Ryanodine, cyclopiazonic acid, thapsigargin, U-73122, and calphostin C also abolished the nicardipine-insensitive component of quick stretch-induced contraction. These results suggest that the slow stretch-induced contraction was exclusively dependent on the Ca<sup>2+</sup> influx through L-type voltage-dependent Ca<sup>2+</sup> channels (VDCs), whereas the quick stretch-induced contraction was dependent on Ca<sup>2+</sup> release from sarcoplasmic reticulum (SR) and Ca<sup>2+</sup> influx through L-type VDCs.<br>

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  • The Japanese journal of physiology

    The Japanese journal of physiology 51(3), 327-335, 2001-06

    PHYSIOLOGICAL SOCIETY OF JAPAN

参考文献:  29件中 1-29件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10008293754
  • NII書誌ID(NCID)
    AA00691224
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    0021521X
  • NDL 記事登録ID
    5840275
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z53-D40
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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