Roles of α_1 and α_1/β Subunits Derived from Cardiac L-Type Ca^<2+> Channels on Voltage-Dependent Facilitation Mechanisms

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Strong depolarization pulses facilitate L-type Ca<sup>2+</sup> channels in various cell types including cardiac myocytes. The mechanisms underlying prepulse facilitation are controversial with respect to the requirements for channel subunits, cAMP-dependent protein kinase, and additional anchor proteins. The properties of voltage-dependent facilitation of the L-type Ca<sup>2+</sup> channel was studied in recombinant cardiac α<sub>1</sub> subunits with or without cardiac β subunit, expressed in Chinese hamster fibroblast cells. The magnitude of voltage-dependent I<sub>Ba</sub> facilitation in the α<sub>1</sub> subunit channel is dependent on the duration of the prepulse as well as on the interval duration between prepulse and test pulse. The characteristics of this facilitation were not affected by coexpression of the β subunit. These results indicate that cardiac α<sub>1</sub> subunits exhibit voltage-dependent facilitation because of their own intrinsic structure, independent of any other accessory subunit or additional regulatory proteins, and that cardiac β subunits have no essential regulatory role at the onset or continuance of the voltage-dependent facilitation.<br>

収録刊行物

  • The Japanese journal of physiology

    The Japanese journal of physiology 51(3), 337-344, 2001-06

    PHYSIOLOGICAL SOCIETY OF JAPAN

参考文献:  35件中 1-35件 を表示

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各種コード

  • NII論文ID(NAID)
    10008293784
  • NII書誌ID(NCID)
    AA00691224
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    0021521X
  • NDL 記事登録ID
    5840287
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z53-D40
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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