Laterality in Direct and Indirect Inotropic Effects of Sympathetic Stimulation in Isolated Canine Heart

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Although sympathetic nerve stimulation is known to increase ventricular contractility, concomitant increases in heart rate (HR) make it difficult to separate its direct inotropic effect from indirect inotropic effect through a force-frequency mechanism. We stimulated the stellate ganglia in 8 isolated canine hearts with functional sympathetic nerves. Right sympathetic stimulation at 10 Hz increased ventricular end-systolic elastance (E<sub>es</sub>) by 95.7 ± 7.5% (p < 0.001) and HR by 32.5 ± 4.2% (p < 0.05). In contrast, left sympathetic stimulation at 10 Hz increased E<sub>es</sub> by 70.7 ± 6.5% (p < 0.001) without significant changes in HR. Preventing the chronotropic response by fixed-rate pacing attenuated the E<sub>es</sub> response to right sympathetic stimulation at 5 Hz (52.0 ± 5.1 vs. 22.8 ± 2.8%, p < 0.001), but not to left sympathetic stimulation at 5 Hz (54.5 ± 3.4 vs. 53.3 ± 2.2%, NS). In the isolated canine heart, the right sympathetic nerve affected E<sub>es</sub> by both the direct inotropic effect and the indirect HR-dependent inotropic effect. In contrast, the left sympathetic nerve regulated E<sub>es</sub> primarily by its direct inotropic effect.<br>

収録刊行物

  • The Japanese journal of physiology

    The Japanese journal of physiology 51(3), 365-370, 2001-06

    PHYSIOLOGICAL SOCIETY OF JAPAN

参考文献:  22件中 1-22件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008293883
  • NII書誌ID(NCID)
    AA00691224
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    0021521X
  • NDL 記事登録ID
    5840317
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z53-D40
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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